Anaphylactoid reaction to vancomycin during general anesthesia in a child patient.

Vancomycin is an antibiotic used primarily For staphylococcal infections. It also is recommended by the American Heart Association For the prevention of subacute bacterial endocarditis in susceptible patients who are allergic to penicillin. Anaphylactic reactions to vancomycin are rare, with only two cases reported in the literature. A case of an anaphylactic reaction to vancomycin in a chiht patient during general anesthesia For dental surgery is reported. The patient had a ventricular septal defect and a penicillin allergy. Vancomycin IV was administered For prophylactic coverage while the patient was under general anesthesia. Immediately after infusion of the antibiotic, signs and symptoms of anaphylaxis ensued, blood pressure dropped rapidly, and a maculopapular rash developed over the patient’s body. Emergency measures were taken, and eventually the patient’s vital signs returned to normal and the rash subsided. Antibiotic coverage utilizing oral erythromycin was continued after completion of